The Sinha Lab

Our laboratory studies key aspects of protein synthesis and translational control in healthy and diseased states. Our research explores the multifaceted roles of ribosomes as a central sensor and effector of cellular stress response.

Specifically, we aim to:

• elucidate how ribosomes detect and respond to ribotoxic stress, and

• identify and characterize ribosome-mediated quality control and signaling pathways that regulate cellular homeostasis and cell fate decisions in response to translational stress.