Publications
Single-protein/RNA imaging reveals ZNF598 as a limiting factor in resolving collided ribosomes
De La Cruz AC, Tisdale G, Nakayama E, Huang Z, Sinha NK, Green R, Wu B.
EMBO J. 2025 Aug 1. PMID: 40750700
The ribotoxic stress response drives UV-mediated cell death
Sinha NK, McKenney C, Yeow ZY, Li JJ, Nam KH, Yaron-Barir TM, Johnson JL, Huntsman EM, Cantley LC, Ordureau A, Regot S, Green R.
Cell. 2024 Jul 11;187(14):3652-3670.e40. Epub 2024 Jun 5.PMID: 38843833
CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication
McKenney C, Lendner Y, Guerrero Zuniga A, Sinha N, Veresko B, Aikin TJ, Regot S.
Science. 2024 May 3;384(6695):eadi2421. Epub 2024 May 3.PMID: 38696576
RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
Zhao S, Cordes J, Caban KM, Götz MJ, Mackens-Kiani T, Veltri AJ, Sinha NK, Weickert P, Kaya S, Hewitt G, Nedialkova DD, Fröhlich T, Beckmann R, Buskirk AR, Green R, Stingele
J.Mol Cell. 2023 Dec 7;83(23):4290-4303.e9. Epub 2023 Nov 10.PMID: 37951216 Free PMC article.
Bursting translation on single mRNAs in live cells
Livingston NM, Kwon J, Valera O, Saba JA, Sinha NK, Reddy P, Nelson B, Wolfe C, Ha T, Green R, Liu J, Wu B.
Mol Cell. 2023 Jul 6;83(13):2276-2289.e11. Epub 2023 Jun 16.PMID: 37329884
Translational repression of NMD targets by GIGYF2 and EIF4E2
Zinshteyn B, Sinha NK, Enam SU, Koleske B, Green R.
PLoS Genet. 2021 Oct 19;17(10):e1009813. eCollection 2021 Oct.PMID: 34665823
GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control
Hickey KL, Dickson K, Cogan JZ, Replogle JM, Schoof M, D'Orazio KN, Sinha NK, Hussmann JA, Jost M, Frost A, Green R, Weissman JS, Kostova KK.
Mol Cell. 2020 Sep 17;79(6):950-962.e6. Epub 2020 Jul 28.PMID: 32726578
EDF1 coordinates cellular responses to ribosome collisions
Sinha NK, Ordureau A, Best K, Saba JA, Zinshteyn B, Sundaramoorthy E, Fulzele A, Garshott DM, Denk T, Thoms M, Paulo JA, Harper JW, Bennett EJ, Beckmann R, Green R.
Elife. 2020 Aug 3;9:e58828. PMID: 32744497
The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay
D'Orazio KN, Wu CC, Sinha N, Loll-Krippleber R, Brown GW, Green R.
Elife. 2019 Jun 20;8:e49117. PMID: 31219035
Dicer uses distinct modules for recognizing dsRNA termini
Sinha NK, Iwasa J, Shen PS, Bass BL.
Science. 2018 Jan 19;359(6373):329-334. Epub 2017 Dec 21.PMID: 29269422
Loquacious-PD facilitates Drosophila Dicer-2 cleavage through interactions with the helicase domain and dsRNA
Trettin KD, Sinha NK, Eckert DM, Apple SE, Bass BL.
Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7939-E7948. Epub 2017 Sep 5.PMID: 28874570
Overexpression and purification of Dicer and accessory proteins for biochemical and structural studies
Sinha NK, Bass BL.
Methods. 2017 Aug 15;126:54-65. Epub 2017 Jul 16.PMID: 28723582
Drosophila dicer-2 cleavage is mediated by helicase- and dsRNA termini-dependent states that are modulated by Loquacious-PD
Sinha NK, Trettin KD, Aruscavage PJ, Bass BL.
Mol Cell. 2015 May 7;58(3):406-17. Epub 2015 Apr 16.PMID: 25891075
Evolutionary complexities of swine flu H1N1 gene sequences of 2009
Sinha NK, Roy A, Das B, Das S, Basak S.
Biochem Biophys Res Commun. 2009 Dec 18;390(3):349-51. Epub 2009 Sep 19.PMID: 19769939 Review.